Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion

Fusion of yeast vacuoles requires the Rab GTPase Ypt7p, four SNAREs (soluble N-ethylmaleimide–sensitive factor attachment protein receptors), the SNARE disassembly chaperones Sec17p/Sec18p, vacuolar lipids, and the Rab-effector complex HOPS (homotypic fusion and vacuole protein sorting). Two HOPS su...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Orr, Amy, Wickner, William, Rusin, Scott F., Kettenbach, Arminja N., Zick, Michael
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294677/
https://ncbi.nlm.nih.gov/pubmed/25411340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-08-1298
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