Safety Profiles and Antitumor Efficacy of Oncolytic Adenovirus Coated with Bioreducible Polymer in the Treatment of a CAR Negative Tumor Model

[Image: see text] Adenovirus (Ad) vectors show promise as cancer gene therapy delivery vehicles, but immunogenic safety concerns and coxsackie and adenovirus receptor (CAR)-dependency have limited their use. Alternately, biocompatible and bioreducible nonviral vectors, including arginine-grafted cat...

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Vydáno v:Biomacromolecules
Hlavní autoři: Jung, Soo-Jung, Kasala, Dayananda, Choi, Joung-Woo, Lee, Soo-Hwan, Hwang, June Kyu, Kim, Sung Wan, Yun, Chae-Ok
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294585/
https://ncbi.nlm.nih.gov/pubmed/25400213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm501116x
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