HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology an...

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Publicado no:Cell Host Microbe
Main Authors: Trama, Ashley M., Moody, M. Anthony, Alam, S. Munir, Jaeger, Frederick H., Lockwood, Bradley, Parks, Robert, Lloyd, Krissey E., Stolarchuk, Christina, Scearce, Richard, Foulger, Andrew, Marshall, Dawn J., Whitesides, John F., Jeffries, Thomas L., Wiehe, Kevin, Morris, Lynn, Lambson, Bronwen, Soderberg, Kelly, Hwang, Kwan-Ki, Tomaras, Georgia D., Vandergrift, Nathan, Jackson, Katherine J.L., Roskin, Krishna M., Boyd, Scott D., Kepler, Thomas B., Liao, Hua-Xin, Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294419/
https://ncbi.nlm.nih.gov/pubmed/25121750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.07.003
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