Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype

Multiple myeloma (MM) cells specifically attract peripheral-blood monocytes, while interaction of MM with bone marrow stromal cells (BMSCs) significantly increased monocyte recruitment (p<0.01). The CXCL12 chemokine, produced by both the MM and BMSCs, was found to be a critical regulator of monoc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Beider, Katia, Bitner, Hanna, Leiba, Merav, Gutwein, Odit, Koren-Michowitz, Maya, Ostrovsky, Olga, Abraham, Michal, Wald, Hanna, Galun, Eithan, Peled, Amnon, Nagler, Arnon
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294328/
https://ncbi.nlm.nih.gov/pubmed/25526031
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