THEMIS Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

We identify an N-ethyl-N-nitrosourea (ENU)-induced I23N mutation in the THEMIS protein that causes protection against experimental cerebral malaria (ECM) caused by infection with Plasmodium berghei ANKA. Themis(I23N) homozygous mice show reduced CD4(+) and CD8(+) T lymphocyte numbers. ECM resistance...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Torre, Sabrina, Faucher, Sebastien P., Fodil, Nassima, Bongfen, Silayuv E., Berghout, Joanne, Schwartzentruber, Jeremy A., Majewski, Jacek, Lathrop, Mark, Cooper, Andrea M., Vidal, Silvia M., Gros, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294254/
https://ncbi.nlm.nih.gov/pubmed/25452553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02586-14
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