An N-Ethyl-N-Nitrosourea (ENU)-Induced Dominant Negative Mutation in the JAK3 Kinase Protects against Cerebral Malaria

Cerebral malaria (CM) is a lethal neurological complication of malaria. We implemented a genome-wide screen in mutagenized mice to identify host proteins involved in CM pathogenesis and whose inhibition may be of therapeutic value. One pedigree (P48) segregated a resistance trait whose CM-protective...

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Hlavní autoři: Bongfen, Silayuv E., Rodrigue-Gervais, Ian-Gael, Berghout, Joanne, Torre, Sabrina, Cingolani, Pablo, Wiltshire, Sean A., Leiva-Torres, Gabriel A., Letourneau, Louis, Sladek, Robert, Blanchette, Mathieu, Lathrop, Mark, Behr, Marcel A., Gruenheid, Samantha, Vidal, Silvia M., Saleh, Maya, Gros, Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283600/
https://ncbi.nlm.nih.gov/pubmed/22363534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031012
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