bis-Molybdopterin Guanine Dinucleotide Is Required for Persistence of Mycobacterium tuberculosis in Guinea Pigs

Mycobacterium tuberculosis is able to synthesize molybdopterin cofactor (MoCo), which is utilized by numerous enzymes that catalyze redox reactions in carbon, nitrogen, and sulfur metabolism. In bacteria, MoCo is further modified through the activity of a guanylyltransferase, MobA, which converts Mo...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Williams, Monique J., Shanley, Crystal A., Zilavy, Andrew, Peixoto, Blas, Manca, Claudia, Kaplan, Gilla, Orme, Ian M., Mizrahi, Valerie, Kana, Bavesh D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Bacterial Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294236/
https://ncbi.nlm.nih.gov/pubmed/25404027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02722-14
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