Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1

Resistance to the human epidermal growth factor receptor (HER2)–targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-positive metastatic breast cancer. Increased expression or signaling from the insulin-like growth factor-1 receptor (IGF-1R) has been reported to be asso...

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Udgivet i:Mol Pharmacol
Main Authors: Sanabria-Figueroa, Eduardo, Donnelly, Siobhan M., Foy, Kevin C., Buss, Meghan C., Castellino, Robert C., Paplomata, Elisavet, Taliaferro-Smith, Latonia, Kaumaya, Pravin T.P., Nahta, Rita
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293451/
https://ncbi.nlm.nih.gov/pubmed/25391374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095380
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