IGF-1R peptide vaccines/mimics inhibit the growth of BxPC3 and JIMT-1 cancer cells and exhibit synergistic antitumor effects with HER-1 and HER-2 peptides

The insulin-like growth factor-1 receptor (IGF-1R) plays a crucial role in cellular growth, proliferation, transformation, and inhibition of apoptosis. A myriad of human cancer types have been shown to overexpress IGF-1R, including breast and pancreatic adenocarcinoma. IGF-1R signaling interferes wi...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Foy, Kevin Chu, Miller, Megan J, Overholser, Jay, Donnelly, Siobhan M, Nahta, Rita, Kaumaya, Pravin TP
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368154/
https://ncbi.nlm.nih.gov/pubmed/25941587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.956005
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