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Suppression of Mitochondrial Biogenesis through Toll-Like Receptor 4–Dependent Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling in Endotoxin-Induced Acute Kidney Injury

Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely accepted pathophysiologic feature of sepsis-induced acute kidney injury (AKI), the molecular mechanisms responsible for this phenomenon are unknown. In this study, we examined the signaling pathways responsible for the...

詳細記述

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書誌詳細
出版年:J Pharmacol Exp Ther
主要な著者: Smith, Joshua A., Stallons, L. Jay, Collier, Justin B., Chavin, Kenneth D., Schnellmann, Rick G.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293437/
https://ncbi.nlm.nih.gov/pubmed/25503387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221085
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