Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury

While disruption of energy production is an important contributor to renal injury, metabolic alterations in sepsis-induced AKI remain understudied. We assessed changes in renal cortical glycolytic metabolism in a mouse model of sepsis-induced AKI. A specific and rapid increase in hexokinase (HK) act...

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Autores principales: Smith, Joshua A., Stallons, L. Jay, Schnellmann, Rick G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137133/
https://ncbi.nlm.nih.gov/pubmed/24990892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00271.2014
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