Feedback suppression of PI3Kα signaling in PTEN mutated tumors is relieved by selective inhibition of PI3Kβ

In PTEN-mutated tumors, we show that PI3Kα activity is suppressed and PI3K signaling is driven by PI3Kβ. A selective inhibitor of PI3Kβ inhibits the Akt/mTOR pathway in these tumors but not in those driven by receptor tyrosine kinases. However, inhibition of PI3Kβ only transiently inhibits Akt/mTOR...

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Опубликовано в: :Cancer Cell
Главные авторы: Schwartz, Sarit, Wongvipat, John, Trigwell, Cath B., Hancox, Urs, Carver, Brett S., Rodrik-Outmezguine, Vanessa, Will, Marie, Yellen, Paige, de Stanchina, Elisa, Baselga, José, Scher, Howard I., Barry, Simon T., Sawyers, Charles L., Chandarlapaty, Sarat, Rosen, Neal
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293347/
https://ncbi.nlm.nih.gov/pubmed/25544636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.008
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