Common Chromosome Fragile Sites in Human and Murine Epithelial Cells and FHIT/FRA3B Loss-Induced Global Genome Instability

Chromosomal positions of common fragile sites differ in lymphoblasts and fibroblasts, with positions dependent on the epigenetically determined density of replication origins at these loci. Because rearrangement of fragile loci and associated loss of fragile gene products are hallmarks of cancers, w...

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Vydáno v:Genes Chromosomes Cancer
Hlavní autoři: Hosseini, Seyed Ali, Horton, Susan, Saldivar, Joshua C., Miuma, Satoshi, Stampfer, Martha R., Heerema, Nyla A., Huebner, Kay
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293015/
https://ncbi.nlm.nih.gov/pubmed/23929738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22097
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