Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord

BACKGROUND AND PURPOSE: Opioid antagonists, such as naloxone and naltrexone, exhibit agonistic properties at the mutated μ receptor, MOR-S196ACSTA. In our previous study, systemic naloxone (10 mg·kg(−1), s.c.) elicited antinociceptive effect without the induction of tolerance, dependence or rewardin...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Kao, Jen-Hsin, Gao, Man-Jun, Yang, Pao-Pao, Law, Ping-Yee, Loh, Horace H, Tao, Pao-Luh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2015
Konular:
Themed Section: Opioids: New Pathways to Functional Selectivity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292974/
https://ncbi.nlm.nih.gov/pubmed/24866991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12790
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