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Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord
BACKGROUND AND PURPOSE: Opioid antagonists, such as naloxone and naltrexone, exhibit agonistic properties at the mutated μ receptor, MOR-S196ACSTA. In our previous study, systemic naloxone (10 mg·kg(−1), s.c.) elicited antinociceptive effect without the induction of tolerance, dependence or rewardin...
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| Udgivet i: | Br J Pharmacol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292974/ https://ncbi.nlm.nih.gov/pubmed/24866991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12790 |
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