In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile

BACKGROUND AND PURPOSE: For patients experiencing inadequate analgesia and intolerable opioid-related side effects on one strong opioid analgesic, pain relief with acceptable tolerability is often achieved by rotation to a second strong opioid. These observations suggest subtle pharmacodynamic diffe...

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Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Kuo, A, Wyse, B D, Meutermans, W, Smith, M T
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2015
Teme:
Themed Section: Opioids: New Pathways to Functional Selectivity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292966/
https://ncbi.nlm.nih.gov/pubmed/24641546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12696
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