Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A

BACKGROUND AND PURPOSE: Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi-synthetic analog...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Simonson, B, Morani, A S, Ewald, A W M, Walker, L, Kumar, N, Simpson, D, Miller, J H, Prisinzano, T E, Kivell, B M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2015
Soggetti:
Themed Section: Opioids: New Pathways to Functional Selectivity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292965/
https://ncbi.nlm.nih.gov/pubmed/24641310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12692
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi