Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A

BACKGROUND AND PURPOSE: Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi-synthetic analog...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Simonson, B, Morani, A S, Ewald, A W M, Walker, L, Kumar, N, Simpson, D, Miller, J H, Prisinzano, T E, Kivell, B M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2015
Assuntos:
Themed Section: Opioids: New Pathways to Functional Selectivity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292965/
https://ncbi.nlm.nih.gov/pubmed/24641310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12692
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