mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues

MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at steady state in the few contexts examined globally. Here, we extend the global steady-state measurements to additional mammalian contexts and f...

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Vydáno v:Mol Cell
Hlavní autoři: Eichhorn, Stephen W., Guo, Huili, McGeary, Sean E., Rodriguez-Mias, Ricard A., Shin, Chanseok, Baek, Daehyun, Hsu, Shu-hao, Ghoshal, Kalpana, Villén, Judit, Bartel, David P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292926/
https://ncbi.nlm.nih.gov/pubmed/25263593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.028
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