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Acute and chronic administration of a low-dose combination of topiramate and ondansetron reduces ethanol’s reinforcing effects in male Alcohol Preferring (P) rats

Topiramate (a GABA/glutamate modulator) and ondansetron (a serotonin-3 antagonist) have shown promise as treatments for alcohol use disorders (AUDs), although efficacy is modest/variable for both medications. We recently showed in animal models of consumption and relapse that acute treatment with a...

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Publicat a:Exp Clin Psychopharmacol
Autors principals: Moore, Catherine F, Lycas, Matthew D, Bond, Colin W, Johnson, Bankole A, Lynch, Wendy J
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292872/
https://ncbi.nlm.nih.gov/pubmed/24490709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1037/a0035215
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