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Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53

BACKGROUND: Understanding how inflammation causes neuronal damage is of paramount importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we addressed the role of the apoptotic cascade in the synaptic abnormalities and neuronal loss caused by the proinflammatory cytokines...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Rossi, Silvia, Motta, Caterina, Studer, Valeria, Macchiarulo, Giulia, Volpe, Elisabetta, Barbieri, Francesca, Ruocco, Gabriella, Buttari, Fabio, Finardi, Annamaria, Mancino, Raffaele, Weiss, Sagit, Battistini, Luca, Martino, Gianvito, Furlan, Roberto, Drulovic, Jelena, Centonze, Diego
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292815/
https://ncbi.nlm.nih.gov/pubmed/25495224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-56
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