Co-blockade of immune checkpoints and adenosine A(2A) receptor suppresses metastasis

Immunosuppressive pathways active within the tumor microenvironment must be targeted in combination to sufficiently bolster antitumor immune defenses. Inhibition of A(2A) adenosine receptor signaling in combination with immune checkpoint blockade enhances CD8(+) T and NK cell anti-metastatic activit...

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Publicat a:Oncoimmunology
Autors principals: Young, Arabella, Mittal, Deepak, Stannard, Kimberley, Yong, Michelle, Teng, Michele WL, Allard, Bertrand, Stagg, John, Smyth, Mark J
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292728/
https://ncbi.nlm.nih.gov/pubmed/25941583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.958952
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