Identification of a Wide Range of Motifs Inhibitory to Shiga Toxin by Affinity-Driven Screening of Customized Divalent Peptides Synthesized on a Membrane

Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli, binds to target cells through a multivalent interaction between its B-subunit pentamer and the cell surface receptor globotriaosylceramide, resulting in a remarkable increase in its binding affinity. This phenomenon i...

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Veröffentlicht in:Appl Environ Microbiol
Hauptverfasser: Kato, Mihoko, Watanabe-Takahashi, Miho, Shimizu, Eiko, Nishikawa, Kiyotaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292467/
https://ncbi.nlm.nih.gov/pubmed/25452283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03517-14
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