Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization

[Image: see text] Lenvatinib is an oral multikinase inhibitor that selectively inhibits vascular endothelial growth factor (VEGF) receptors 1 to 3 and other proangiogenic and oncogenic pathway-related receptor tyrosine kinases. To elucidate the origin of the potency of lenvatinib in VEGF receptor 2...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Okamoto, Kiyoshi, Ikemori-Kawada, Megumi, Jestel, Anja, von König, Konstanze, Funahashi, Yasuhiro, Matsushima, Tomohiro, Tsuruoka, Akihiko, Inoue, Atsushi, Matsui, Junji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2014
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291723/
https://ncbi.nlm.nih.gov/pubmed/25589937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500394m
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