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HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation
Increasing evidence has demonstrated that epigenetic factors can profoundly influence gene expression and, in turn, influence resistance or susceptibility to disease. Epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, are finding their way into clinical practice, although their exact m...
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出版年: | Proc Natl Acad Sci U S A |
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主要な著者: | , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
National Academy of Sciences
2015
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291662/ https://ncbi.nlm.nih.gov/pubmed/25535382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415195112 |
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