HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Increasing evidence has demonstrated that epigenetic factors can profoundly influence gene expression and, in turn, influence resistance or susceptibility to disease. Epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, are finding their way into clinical practice, although their exact m...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Jia, Haiqun, Morris, Charles D., Williams, Roy M., Loring, Jeanne F., Thomas, Elizabeth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291662/
https://ncbi.nlm.nih.gov/pubmed/25535382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415195112
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