Transdermal deferoxamine prevents pressure-induced diabetic ulcers

There is a high mortality in patients with diabetes and severe pressure ulcers. For example, chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Duscher, Dominik, Neofytou, Evgenios, Wong, Victor W., Maan, Zeshaan N., Rennert, Robert C., Inayathullah, Mohammed, Januszyk, Michael, Rodrigues, Melanie, Malkovskiy, Andrey V., Whitmore, Arnetha J., Walmsley, Graham G., Galvez, Michael G., Whittam, Alexander J., Brownlee, Michael, Rajadas, Jayakumar, Gurtner, Geoffrey C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291638/
https://ncbi.nlm.nih.gov/pubmed/25535360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413445112
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