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Only three driver gene mutations are required for the development of lung and colorectal cancers
Cancer arises through the sequential accumulation of mutations in oncogenes and tumor suppressor genes. However, how many such mutations are required for a normal human cell to progress to an advanced cancer? The best estimates for this number have been provided by mathematical models based on the r...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291633/ https://ncbi.nlm.nih.gov/pubmed/25535351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421839112 |
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