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Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies, the underlying mechanisms remain poorly understood. Here we develop a microfluidic 3D in vitro model to analyze organ-specific human breast canc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jeon, Jessie S., Bersini, Simone, Gilardi, Mara, Dubini, Gabriele, Charest, Joseph L., Moretti, Matteo, Kamm, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291627/
https://ncbi.nlm.nih.gov/pubmed/25524628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417115112
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