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OTOTOXIC EFFECTS OF CARBOPLATIN IN ORGANOTYPIC CULTURES IN CHINCHILLAS AND RATS

Carboplatin, a second-generation platinum chemotherapeutic drug, is considerably less ototoxic than cisplatin. While common laboratory species such as mice, guinea pigs and rats are highly resistant to carboplatin ototoxicity, the chinchilla stands out as highly susceptible. Moreover, carboplatin ca...

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Bibliographic Details
Published in:J Otol
Main Authors: Dalian, Ding, Haiyan, Jiang, Yong, Fu, Salvi, Richard, Someya, Shinichi, Tanokura, Masaru
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291553/
https://ncbi.nlm.nih.gov/pubmed/25593588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1672-2930(12)50023-1
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