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Loss of the Notch effector RBPJ promotes tumorigenesis
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and conse...
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| Publicado en: | J Exp Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291530/ https://ncbi.nlm.nih.gov/pubmed/25512468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121192 |
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