Loss of the Notch effector RBPJ promotes tumorigenesis

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and conse...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Kulic, Iva, Robertson, Gordon, Chang, Linda, Baker, Jennifer H.E., Lockwood, William W., Mok, Winnie, Fuller, Megan, Fournier, Michèle, Wong, Nelson, Chou, Vennie, Robinson, Mark D., Chun, Hye-Jung, Gilks, Blake, Kempkes, Bettina, Thomson, Thomas A., Hirst, Martin, Minchinton, Andrew I., Lam, Wan L., Jones, Steven, Marra, Marco, Karsan, Aly
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291530/
https://ncbi.nlm.nih.gov/pubmed/25512468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121192
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