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Loss of the Notch effector RBPJ promotes tumorigenesis
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and conse...
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| Publicat a: | J Exp Med |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291530/ https://ncbi.nlm.nih.gov/pubmed/25512468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121192 |
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