Loss of the Notch effector RBPJ promotes tumorigenesis

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and conse...

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Published in:J Exp Med
Main Authors: Kulic, Iva, Robertson, Gordon, Chang, Linda, Baker, Jennifer H.E., Lockwood, William W., Mok, Winnie, Fuller, Megan, Fournier, Michèle, Wong, Nelson, Chou, Vennie, Robinson, Mark D., Chun, Hye-Jung, Gilks, Blake, Kempkes, Bettina, Thomson, Thomas A., Hirst, Martin, Minchinton, Andrew I., Lam, Wan L., Jones, Steven, Marra, Marco, Karsan, Aly
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291530/
https://ncbi.nlm.nih.gov/pubmed/25512468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121192
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