Loss of the Notch effector RBPJ promotes tumorigenesis

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and conse...

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Publicado en:J Exp Med
Main Authors: Kulic, Iva, Robertson, Gordon, Chang, Linda, Baker, Jennifer H.E., Lockwood, William W., Mok, Winnie, Fuller, Megan, Fournier, Michèle, Wong, Nelson, Chou, Vennie, Robinson, Mark D., Chun, Hye-Jung, Gilks, Blake, Kempkes, Bettina, Thomson, Thomas A., Hirst, Martin, Minchinton, Andrew I., Lam, Wan L., Jones, Steven, Marra, Marco, Karsan, Aly
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291530/
https://ncbi.nlm.nih.gov/pubmed/25512468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121192
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