Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis

Transgenic mice expressing the Notch 4 intracellular domain (ICD) (Int3) in the mammary gland have two phenotypes: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch4 signaling is mediated primarily through the interaction of Int3 with the transcription repressor/activat...

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Autores principales: Raafat, A, Lawson, S, Bargo, S, Klauzinska, M, Strizzi, L, Goldhar, AS, Buono, K, Salomon, D, Vonderhaar, BK, Callahan, R
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794555/
https://ncbi.nlm.nih.gov/pubmed/18836481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.379
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