In Vivo Selection of Plasmodium falciparum Pfcrt and Pfmdr1 Variants by Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine in Burkina Faso

Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Baraka, Vito, Tinto, Halidou, Valea, Innocent, Fitzhenry, Robert, Delgado-Ratto, Christopher, Mbonye, Martin K., Van Overmeir, Chantal, Rosanas-Urgell, Anna, Van geertruyden, Jean-Pierre, D'Alessandro, Umberto, Erhart, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291431/
https://ncbi.nlm.nih.gov/pubmed/25403659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03647-14
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