Effects of Dihydroartemisinin-Piperaquine Phosphate and Artemether-Lumefantrine on QTc Interval Prolongation

QT/QTc interval prolongation reflects delayed cardiac repolarization which can lead to Torsade de Pointes and sudden death. Many antimalarial drugs prolong QT/QTc interval. However, due to confounding factors in patients with malaria, the precise extent of this effect has been found to be highly var...

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Udgivet i:Sci Rep
Main Authors: Funck-Brentano, Christian, Bacchieri, Antonella, Valentini, Giovanni, Pace, Silvia, Tommasini, Silva, Voiriot, Pascal, Ubben, David, Duparc, Stephan, Evene, Eric, Felices, Mathieu, Corsi, Marco
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349839/
https://ncbi.nlm.nih.gov/pubmed/30692558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37112-6
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