The Investigational Agent E1210 Is Effective in Treatment of Experimental Invasive Candidiasis Caused by Resistant Candida albicans

The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandin-resistant C. albicans, oral doses of 10 and 40 mg...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wiederhold, Nathan P., Najvar, Laura K., Fothergill, Annette W., McCarthy, Dora I., Bocanegra, Rosie, Olivo, Marcos, Kirkpatrick, William R., Everson, Michael P., Duncanson, Frederick P., Patterson, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291422/
https://ncbi.nlm.nih.gov/pubmed/25331706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03944-14
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