The Novel Arylamidine T-2307 Maintains In Vitro and In Vivo Activity against Echinocandin-Resistant Candida albicans

We evaluated the in vitro and in vivo activities of the investigational arylamidine T-2307 against echinocandin-resistant Candida albicans. T-2307 demonstrated potent in vitro activity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced f...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Wiederhold, Nathan P., Najvar, Laura K., Fothergill, Annette W., Bocanegra, Rosie, Olivo, Marcos, McCarthy, Dora I., Kirkpatrick, William R., Fukuda, Yoshiko, Mitsuyama, Junichi, Patterson, Thomas F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335842/
https://ncbi.nlm.nih.gov/pubmed/25451054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04228-14
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