The Novel Arylamidine T-2307 Selectively Disrupts Yeast Mitochondrial Function by Inhibiting Respiratory Chain Complexes

The novel arylamidine T-2307 exhibits broad-spectrum in vitro and in vivo antifungal activities against clinically significant pathogens. Previous studies have shown that T-2307 accumulates in yeast cells via a specific polyamine transporter and disrupts yeast mitochondrial membrane potential. Furth...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Yamashita, Kohei, Miyazaki, Taiga, Fukuda, Yoshiko, Mitsuyama, Junichi, Saijo, Tomomi, Shimamura, Shintaro, Yamamoto, Kazuko, Imamura, Yoshifumi, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, Mukae, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658782/
https://ncbi.nlm.nih.gov/pubmed/31182539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00374-19
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