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Mechanism of β-Lactam Action in Streptococcus pneumoniae: the Piperacillin Paradox

The human pathogen Streptococcus pneumoniae has been treated for decades with β-lactam antibiotics. Its resistance is now widespread, mediated by the expression of mosaic variants of the target enzymes, the penicillin-binding proteins (PBPs). Understanding the mode of action of β-lactams, not only i...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Philippe, Jules, Gallet, Benoit, Morlot, Cécile, Denapaite, Dalia, Hakenbeck, Regine, Chen, Yuxin, Vernet, Thierry, Zapun, André
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291406/
https://ncbi.nlm.nih.gov/pubmed/25385114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04283-14
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