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An Important Site in PBP2x of Penicillin-Resistant Clinical Isolates of Streptococcus pneumoniae: Mutational Analysis of Thr338

Penicillin-binding protein 2x (PBP2x) of Streptococcus pneumoniae represents a primary resistance determinant for beta-lactams, and low-affinity PBP2x variants can easily be selected with cefotaxime. Penicillin-resistant clinical isolates of S. pneumoniae frequently contain in their mosaic PBP2x the...

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Detalhes bibliográficos
Main Authors: Zerfaß, Ilka, Hakenbeck, Regine, Denapaite, Dalia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650557/
https://ncbi.nlm.nih.gov/pubmed/19075056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01107-08
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