A Low-Affinity Penicillin-Binding Protein 2x Variant Is Required for Heteroresistance in Streptococcus pneumoniae

Heteroresistance to penicillin in Streptococcus pneumoniae is the ability of subpopulations to grow at a higher antibiotic concentration than expected from the MIC. This may render conventional resistance testing unreliable and lead to therapeutic failure. We investigated the role of the primary β-l...

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Bibliographic Details
Main Authors: Engel, Hansjürg, Mika, Moana, Denapaite, Dalia, Hakenbeck, Regine, Mühlemann, Kathrin, Heller, Manfred, Hathaway, Lucy J., Hilty, Markus
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068597/
https://ncbi.nlm.nih.gov/pubmed/24777105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02547-14
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