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Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

Nephrotoxicity is the major dose-limiting factor for the clinical use of colistin against multidrug-resistant (MDR) Gram-negative bacteria. This study aimed to investigate the protective effect of lycopene on colistin-induced nephrotoxicity in a mouse model. Fifty mice were randomly divided into 5 g...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Dai, Chongshan, Tang, Shusheng, Deng, Sijun, Zhang, Shen, Zhou, Yan, Velkov, Tony, Li, Jian, Xiao, Xilong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291401/
https://ncbi.nlm.nih.gov/pubmed/25385104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03925-14
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