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Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species
Artemisinin-based combination therapy (ACT) is the recommended first-line treatment for Plasmodium falciparum malaria. It has been suggested that the cytotoxic effect of artemisinin is mediated by free radicals followed by the alkylation of P. falciparum proteins. The endoperoxide bridge, the active...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291367/ https://ncbi.nlm.nih.gov/pubmed/25348537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03663-14 |
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