The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug

Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although these molecules have multiple deleterious effects on fungal cells, their specif...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Mesa-Arango, Ana Cecilia, Trevijano-Contador, Nuria, Román, Elvira, Sánchez-Fresneda, Ruth, Casas, Celia, Herrero, Enrique, Argüelles, Juan Carlos, Pla, Jesús, Cuenca-Estrella, Manuel, Zaragoza, Oscar
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249417/
https://ncbi.nlm.nih.gov/pubmed/25155595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03570-14
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