The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug

Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although these molecules have multiple deleterious effects on fungal cells, their specif...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Mesa-Arango, Ana Cecilia, Trevijano-Contador, Nuria, Román, Elvira, Sánchez-Fresneda, Ruth, Casas, Celia, Herrero, Enrique, Argüelles, Juan Carlos, Pla, Jesús, Cuenca-Estrella, Manuel, Zaragoza, Oscar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Mechanisms of Action: Physiological Effects
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249417/
https://ncbi.nlm.nih.gov/pubmed/25155595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03570-14
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