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Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus

Drug resistance in fungal pathogens is of incredible importance to global health, yet the mechanisms of drug action remain only loosely defined. Antifungal compounds have been shown to trigger the intracellular accumulation of reactive oxygen species (ROS) in human-pathogenic yeasts, but the source...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Shekhova, Elena, Kniemeyer, Olaf, Brakhage, Axel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655112/
https://ncbi.nlm.nih.gov/pubmed/28848005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00978-17
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