Probing the Molecular Mechanism of Hypericin-Induced Parasite Death Provides Insight into the Role of Spermidine beyond Redox Metabolism in Leishmania donovani

Hypericin, a natural compound from Hypericum perforatum (St. John's wort), has been identified as a specific inhibitor of Leishmania donovani spermidine synthase (LdSS) using integrated computational and biochemical approaches. Hypericin showed in vitro inhibition of recombinant LdSS enzyme act...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Singh, Shalini, Sarma, Shyamali, Katiyar, Shashank P., Das, Mousumi, Bhardwaj, Ruchika, Sundar, Durai, Dubey, Vikash Kumar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291343/
https://ncbi.nlm.nih.gov/pubmed/25313212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04169-14
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