Electron Microscopy in Rat Brain Slices Reveals Rapid Accumulation of Cisplatin on Ribosomes and Other Cellular Components Only in Glia

Cisplatin is a widely used, effective anticancer drug. Its use, however, is associated with several side effects including nephrotoxicity and neurotoxicity. It is known that cisplatin is accumulated in cells by the organic cation transport system and reacts with nucleotides, damaging them, but the p...

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Dettagli Bibliografici
Pubblicato in:Chemother Res Pract
Autori principali: Zueva, Lidia, Rivera, Yomarie, Kucheryavykh, Lilia, Skatchkov, Serguei N., Eaton, Misty J., Sanabria, Priscila, Inyushin, Mikhail
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2014
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291194/
https://ncbi.nlm.nih.gov/pubmed/25610648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/174039
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