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Electron Microscopy in Rat Brain Slices Reveals Rapid Accumulation of Cisplatin on Ribosomes and Other Cellular Components Only in Glia

Cisplatin is a widely used, effective anticancer drug. Its use, however, is associated with several side effects including nephrotoxicity and neurotoxicity. It is known that cisplatin is accumulated in cells by the organic cation transport system and reacts with nucleotides, damaging them, but the p...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Chemother Res Pract
Κύριοι συγγραφείς: Zueva, Lidia, Rivera, Yomarie, Kucheryavykh, Lilia, Skatchkov, Serguei N., Eaton, Misty J., Sanabria, Priscila, Inyushin, Mikhail
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Hindawi Publishing Corporation 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291194/
https://ncbi.nlm.nih.gov/pubmed/25610648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/174039
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