Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease

Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca(2+). Equilibrium gel distribution experiments show that this complex is...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Averna, Monica, De Tullio, Roberta, Pedrazzi, Marco, Bavestrello, Margherita, Pellegrini, Matteo, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289065/
https://ncbi.nlm.nih.gov/pubmed/25575026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116738
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