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Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease
Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca(2+). Equilibrium gel distribution experiments show that this complex is...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4289065/ https://ncbi.nlm.nih.gov/pubmed/25575026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116738 |
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