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A review and re-interpretation of a group-sequential approach to sample size re-estimation in two-stage trials

In this paper, we review the adaptive design methodology of Li et al. (Biostatistics 3:277–287) for two-stage trials with mid-trial sample size adjustment. We argue that it is closer in principle to a group sequential design, in spite of its obvious adaptive element. Several extensions are proposed...

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Vydáno v:Pharm Stat
Hlavní autoři: Bowden, J, Mander, A
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288989/
https://ncbi.nlm.nih.gov/pubmed/24692348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1613
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